YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Facile Synthesis of 2-(4-Biphenylyl)butyric Acid

2-(4-비페닐일)부티르산의 합성

  • Choi, Hong-Dae (Department of Chemistry, Dongeui University) ;
  • Yun, Ho-Sang (Department of Chemistry, Dongeui University) ;
  • Kang, Byung-Won (Department of Chemistry, Dongeui University) ;
  • Son, Byeng-Wha (Department of Chemistry, National Fisheries University of Pusan) ;
  • Jung, Woo-Jin (Department of Chemistry, National Fisheries University of Pusan)
  • Published : 1992.04.29
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Abstract

A new method for xenbucin, which is a antihypercholesteremic agent, is described. Friedel-Crafts reaction of biphenyl with ethyl ${\alpha}-chloro-{\alpha}-(methylthio)acetate(1)$ afforded ethyl 2-methylthio-2-(4-biphenylyl)acetate(2). Ethyl 2-(4-biphenylyl)butyrate(4) was obtained by ethylation of (2) with NaH and $C_2H_5I$, followed by desulfurization of the resultant ethyl 2-methylthio-2-(4-biphenylyl)butyrate(3) with zinc dust in acetic acid. Xenbucin was synthesized by hydrolysis of (4).

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