YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Chemistry and Anti-inflammatory Activity of Prunus davidiana Stems

산복사 줄기의 성분과 항염증 작용

  • Choi, Jae-Sue (Dept. of Nutrition and Food Science, National Fisheries University of Pusan) ;
  • Young, Han-Suk (College of Pharmacy, Pusan National University) ;
  • Lee, Tae-Woong (College of Pharmacy, Pusan National University) ;
  • Woo, Won-Sick (Natural Product Research Institute, Seoul National University) ;
  • Lee, Eun-Bang (Natural Product Research Institute, Seoul National University)
  • Published : 1992.04.29
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Abstract

The possibility as an anti-inflammatory drug of Prunus davidiana which have been used in Korean folk medicine for treatment of neuritis and rheumatism was investigated on carrageenin-induced paw edema in rats. The MeOH extract exhibited potent inhibitory effect on carrageenin-edema rats when topically applicated. On the other hand, it did not show any effect when orally tested. It also had no influences on isolated ileum of guinea pig and anti-platelet aggregating activities. Thus, it appears from the present findings that the MeOH extract of P. davidiana may be utilizable only for the external treatment of inflammed sites. This study was also conducted to further isolation of flavonoids from the EtOAc soluble fraction and characterized as persiconin and isosakuranin by spectrometric analysis.

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