Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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INFLUENCE OF OCHRATOXIN A-INDUCED NEPHROTOXICITY ON THE PHARMACOKINETICS OF GENTAMICIN IN RATS

  • Son, Deok-Soo (Department of viterinary Medicine Kon kuk University) ;
  • Han, Sang-Seop (Department of viterinary Medicine Kon kuk University)
  • Published : 1991.06.01
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Abstract

To evaluate the influence of ochratoxin A on the pharmarcokinetics of gentamicin, gentamicin concentrations in the serum, renal cortex and medulla together with parameters of the renal function and histological changes were compared between ochratoxin A-treated rats (0.1 mg of ochratoxin A/kg of body weight, ip, daily for 14 days) and normal rats. Gentamicin was given with a single intramuscular injection (10mg/kg of body weight). Ochratoxin A resulted in an increase of the half-life, the area under the concentration-time curve, the apparent volume of distribution and a decrease of the total body clearance of gentamicin, and accumulated significantly (p<0.01) more gentamicin in the kidneys.

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References

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