Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
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Studies on Combined Usage of Combined Preparation of Crude Drugs and Anti-neoplastic Drugs (I) -Alleviative Effect of Combined Usage of Gamisamryungbaekchool-San and cis-Platin on the Side Actions of cis-Platin-

생약복합제제(生藥複合製劑)와 항암제(抗癌劑)의 병용투여(倂用投與)에 관한 연구(硏究) (제1보)(第1報) -가미삼령백출산(加味蔘笭白朮散)과 cis-Platin 병용투여(倂用投與)에 의한 부작용(副作用) 경감(輕減) 효과(效果)-

  • Kim, Nam-Jae (East-West Medical Research Institute, Kyung Hee University) ;
  • Hong, Nam-Doo (East-West Medical Research Institute, Kyung Hee University) ;
  • Cho, Chong-Kwan (College of Oriental Medicine, Daejeon University) ;
  • Kim, Jin-Sik (East-West Medical Research Institute, Kyung Hee University) ;
  • Baek, Seung-Hak (College of Oriental Medicine, Daejeon University)
  • 김남재 (경희대학교 동서의학연구소) ;
  • 홍남두 (경희대학교 동서의학연구소) ;
  • 조종관 (대전대학교 한의과대학) ;
  • 김진식 (경희대학교 동서의학연구소) ;
  • 백승학 (대전대학교 한의과대학)
  • Published : 1991.09.30
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Abstract

The water extract of Gamisamryungbaekchool-San increased the lifespan of mice implanted intraperitoneally with sarcoma 180. Significant depression of lethal toxicity of cis-platin $(45{\mu}M/kg,\;s.c)$ and renal toxicity (indicated by an increase in blood urea nitrogen value and creatinine value) of cis-platin $(35{\mu}M/kg,\;s.c)$ were observed in mice and rats treated with Gamisamryungbaekchool-San. RBC and WBC were significantly decreased in rats treated with cis-platin, and significant depression of hematologic toxicities of cis-platin $(35{\mu}M/kg,\;s.c)$ in rats treated with Gamisamryungbaekchool-San. After all, alleviative effect of the side actions of cis-platin was acknowledged by combined usage of Gamisamryungbaekchool-San and cis-platin.

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