Journal of Pharmaceutical Investigation
- Volume 20 Issue 3
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- Pages.129-134
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- 1990
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Preparation and Dissolution Properties of Ftorafur-Galatin Microcapsules
후토라훌-젤라틴 마이크로캅셀의 제조 및 용출특성에 관한 연구
- Lee, Su-Jung (College of Pharmacy, Ewha Womans University) ;
- Kim, Kil-Soo (College of Pharmacy, Ewha Womans University)
- Published : 1990.09.20
Abstract
Gelatin microcapsules containing Ftorafur, a hydrophilic anticancer agent, were prepared with congealable disperse-phase emulsification method. The preparation was based on dispersion of ftorafur-gelatin solution with Tween #40 or Span #20 in liquid paraffin. A cationic surfactant, benzethonium chloride, was used to prevent the microcapsules from aggregation. In the case of microcapsules prepared with Tween #40 or Span #20, mean particle size decreased and narrow size distribution was observed. The intrinsic dissolution rate of ftorafur in microcapsules with 1% span #20 was 8.5 times lower than that of intact ftorafur.