Toxicological Research
- Volume 5 Issue 1
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- Pages.37-41
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- 1989
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
EFFECTS OF DICHLOROMETHANE ON CARBON TETRACHLORIDE HEPATOTOXICITY IN RATS
- Kim, Dae B. (Division of Special Toxicity, Department of Toxicolony, National Institute of Safety Research) ;
- Kim, Baik H. (College of Pharmacy Seoul National University)
- Published : 1989.06.01
Abstract
A non-hepatotoxic dose of dichloromethane (DCM) was examined for potential effects on the hepatotoxicity of carbon tetrachloride (CT) in adult male rats. A concomitant treatment of DCM (0.45ml/kg, po) significantly potentiated the hepatotoxicity of CT at varing doses (0.06 to 0.63 ml/kg, po) as determined by increase in SGOT and SGPT activities 24 hn following the treatments. The carboxyhemoglobin (COHb) saturation induced by DCM was significantly decreased by CT treatments. The potentiation of CT hepatotoxicity by DCM does not appear to be associated with increased metabolism of CT.
Keywords
- Dichloromethane;
- Carbon tetrachloride;
- Combination;
- Carboxyhemoglobin;
- Hepatotoxicity;
- Mixed-function oxidase