Toxicological Research
- Volume 5 Issue 1
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- Pages.27-35
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- 1989
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- 1976-8257(pISSN)
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- 2234-2753(eISSN)
MICROCIRCULATORY ABERRATIONS IN THE ISOLATED PERFUSED RAT LIVER INDUCED BY SODIUM CYANIDE, ANOXIA OR ACETAMINOPHEN
- Jung, Kihwa (Department Pharmacy Cpllege of Pharmacy, Duksung Womens University)
- Published : 1989.06.01
Abstract
When acetaminophen (25mM) was introduced into the perfused rat liver, the hepatic O2 uptake was rapidly inhibited first and then later slow-down. The rapid inhibition was found to be due to mitochondrial blockade, whereas the so-called slow inhibition" was associated with microcirulatory aberrations as evidenced by inhomogneous staining of the liver tissue by trypan blue infusion (0.1%). NaCN (0.5mM) also caused rapid and slow respiratory inhibitions, giving heterogeneous trypan blue staining.ning.
Keywords
- Microcirculatory aberration;
- Acetaminophen hepatotoxicity;
- Perfused liver;
- Hepatic respiration;
- Local ischemia