Journal of Pharmaceutical Investigation
- Volume 19 Issue 4
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- Pages.179-183
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- 1989
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
pH-Dependent Drug Release from Polymethacrylic Acid Hydrogel Matrix
Polymethacrylic Acid 하이드로겔 매트릭스로부터의 pH 의존성 약물 방출
- Kim, Kyung-Chung (College of Pharmacy, Ewha Womans University) ;
- Kim, Kil-Soo (College of Pharmacy, Ewha Womans University) ;
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Lee, Seung-Jin
(College of Pharmacy, Ewha Womans University)
- Published : 1989.12.20
Abstract
Drug release experiments were performed based on pH-sensitive swelling behaviors of polymethacrylic acid. 5-Fluorouracil as a nonionic model drug revealed release patterns depending solely on pH-dependent swelling kinetics of polymethacrylic acid. In contrast, release of propranolol hydrochloride as a cationic model drug was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics. Accordingly, a zero-order release pattern was obtained at pH 7, which was distinguished from the general matrix type drug release pattern.
Keywords
- polyrnethacrylic acid;
- hydrogel matrix;
- pH-dependent drug release;
- swelling kinetics;
- ionic drug-polymer interaction;
- zero-order release