Archives of Pharmacal Research
- 제12권1호
- /
- Pages.8-11
- /
- 1989
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Some Nucleophilic Substitutions in 2,4- and 2,4,8-Trichloro- pyrido [3,2-d] pyrimidines
- Boyomi, Said M. (Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University) ;
- Ismaiel, Abdel-Kader M. (Department of Medicinal Chemistry, Faculty of Pharmancy, University of Mansoura) ;
- Eisa, Hassan M. (Department of Medicinal Chemistry, Faculty of Pharmancy, University of Mansoura) ;
- El-Kerdawy, Mohamed M. (Department of Medicinal Chemistry, Faculty of Pharmancy, University of Mansoura)
- 발행 : 1989.03.01
초록
Reaction of 6-(acetoxymethyl) -2,4-dichloropyrido [3,2-d] pyrimidine (I) with some nucleophiles was investigated. When I reacted with sodium azide afforded 2,4-diazido derivative (II). Treatment of II with sodium hydroxide underwent cyclization of the 2-azido group to tetrazolo, replacement of 4-azido group by hydroxide ion, and hydrolysis of 6-ace-foxy moiety to hydroxy methyl derivative (III). While, reaction of I with hydrazine hydrate resulted in the formation of 2,4 dihydrozino-6-hydroxymethyl derivative (lV).