약학회지 (YAKHAK HOEJI)
- 제33권6호
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- Pages.333-338
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- 1989
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
중추 ${\alpha}_2$ -수용체 자극에 대한 선천성 고혈압쥐의 중추 노르아드레날린성 신경계 반응의 특성
Characteristics of Central Noradrenergic Nervous System Response in SHR to Stimulation of Central ${\alpha}_2-Adrenoceptor$
- Chung, Hye-Joo (College of Pharmacy, Seoul National University) ;
- Oh, Uh-Taek (College of Pharmacy, Seoul National University) ;
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Ko, Kwang-Ho
(College of Pharmacy, Seoul National University)
- 발행 : 1989.12.28
초록
It has been postulated that abnormal characteristics of central noradrenergic nervous system has been implicated in the development and maintenance of hypertension in several modes of experimental hypertension including spontaneously hypertensive rats (SHR). In the present study, we attempt to determine if abnormal characteristics of central noradrenergic nervous system in SHR is caused by genetic factors or hypertensive phenomena by evaluating the changes of central adrenoceptors after long-term treatment of clonidine. Animals were divided into three groups; (1) 14 week-old SHR; (2) age-matched normotensive Wistar rats (NW); (3) DOCA-Salt induced hypertensive rats (DS). Clonidine (100 ug/kg) or vehicle was injected intraperitonealy twice a day for 15 days. Changes of
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