약학회지 (YAKHAK HOEJI)
- 제33권6호
- /
- Pages.324-332
- /
- 1989
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Sodium Tripolyphosphate-Chitosan의 Polyelectrolyte Complex Coating이 Sulfanilamide 과립의 용출에 미치는 영향
The Effect on the Dissolution Rate of Sulfanilamide Granules Coated with a Polyelectrolyte Complex of Sodium Tripolyphosphate-Chitosan
- Ku, Young-Soon (College of Pharmacy, Ewha Womans University) ;
- Kim, Ja-Young (College of Pharmacy, Ewha Womans University) ;
-
Kim, Kil-Soo
(College of Pharmacy, Ewha Womans University)
- 발행 : 1989.12.28
초록
Drug release from sulfanilamide granules coated with a polyelectrlyte complex of sodium tripolyphosphate and chitosan was studied. The coating film thickness increased with increasing concentration of chitosan in the coating solution and the drug release rates of the coated granules were significantly reduced comparing with those of the uncoated granules.