YAKHAK HOEJI (약학회지)
- Volume 33 Issue 5
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- Pages.273-279
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- 1989
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Synthesis of Anticoagulant 3-(N-Arylamino)-1,4-Naphthoquinones(II)
항응고성의 3-(N-Arylamino)-1,4-Naphthoquinone 유도체 합성(II)
- Ryu, Chung-Kyu (College of Pharmacy, Ewha Womans University) ;
- Oh, Jae-Don (College of Pharmacy, Ewha Womans University) ;
- Suh, Myung-Eun (College of Pharmacy, Ewha Womans University)
- Published : 1989.10.28
Abstract
2,3-Dichloro-1,4-naphthoquinone was reacted with o-fluoroaniline, p-sulfadiazine, p-acetoanline, N,N-dimethyl-1,4-phenylenediamine as a nucleophilic substitution to form 2-chloro-3-(N-arylamino)-1,4-naphthoquinones (1.-6.) in good yield. 2,3-Dibromo-1,4-naphthoquinone was also reacted with o-fluoroaniline, m-aminobenzoic acid, m-chloroaniline, morpholine, p-acetoaniline, N,N-dimethyl-1,4-phenylenediamine as a nucleophilic substitution to give 2-bromo-3-(N-arylamino)-1,4-naphthoquinones (7.-12.). These new compounds are expected to have a biological activities such as anticoagulant, cytotoxic.