약학회지 (YAKHAK HOEJI)
- 제33권4호
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- Pages.219-225
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- 1989
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
1,4-디하드로피리딘 산류의 합성(II)
Synthesis of 1,4-Dihydropyridine Carboxylic Acids (II)
- Suh, Jung-Jin (Yuhan Research Center) ;
- Hong, You-Hwa (Yuhan Research Center)
- 발행 : 1989.08.28
초록
2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl 5-(2'-methylthio)ethyl ester methyl iodide salt (7a) was hydrolyzed by treatment with NaOH in aquous EtOH solution to give 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid mono methyl ester (2b) in 88% yield. By the same procedure, 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridinine-3,5-dicarboxylic acid 3-mono isopropyl ester (2c), 2,6-dimethyl-4-(2'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2d), 2,6-dimethyl-4-(2',3'-dichlorophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-mono methyl ester (2e) and 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridin-3,5-dicarboxylic acid (2f) were obtained from the methyl iodide salts in 91-98% yield.
키워드
- 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-methyl-5-(2'-methylthio) ethyl ester methyl iodide salt;
- hydrolyze;
- 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid mono methyl ester;
- 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicaboxylic acid 3-mono isopropyl ester;