Effect of Carbon Tetrachloride Intoxication on the Type Conversion of Xanthine Dehydrogenase Into Xanthine Oxidase in Rats

  • Yoon, Chong-Guk (Department of Public Health, College of Natural Science, Keimyung University) ;
  • Huh, Keun (Department of Pharmacology, College of Pharmacy, Yeungnam University)
  • Published : 1987.03.01

Abstract

The conversion of xanthine dehydrogenase (type D) into xanthine oxidase (type D) was significantly increased in serum and liver of all $CCI_4$ treated rats on the necrosis and early cirrhosis stage of liver tissue. In the pretreatment of prednisolone, the ratio of type O per type O + D showed the decreasing tendency in serum, but the significant decrease in liver. In vitro, the conversion of liver xanthine oxidase from type D into type O was markedly increased by following preincubation with lysosomal fraction. The type conversion of xanthine oxidase may be caused by protelytic enzymes in lysosome.

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