Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXV) -Effect of Woohwangchungsim-Won on the Cardiovascular System-

생약복합제제(生藥複合製劑)의 약효연구(藥效硏究)(제35보)(第35報) -우황청심원(牛黃淸心元)이 순환기계(循環器系)에 미치는 영향(影響)-

Woohwangchungsim-Won has been widely used for the treatment of appoplexy, hypertension, arteriosclerosis, insomnia and cerebrovascular accident, etc in oriental hospital and pharmacy. In order to investigate the efficacy of Woohwangchungsim-Won, the water extract of it were bioassayed for isolated ileum, blood vessels, blood pressure, heart and diuresis. The results of this studies were as follows; Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contraction of isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were inhibited. Vaso-dilating action due to vascular smooth muscle relaxation in frogs and rabbits, and hypotensive action in anesthetized rabbits were noted. Negative inotropic action on the isolated frog heart and diuretic effect in rabbits were shown.