Clinicopathological Changes in Korean Black Goats Administered with Carbon Tetrachloride

사염화탄소를 투여한 한국 흑염소에 있어서 임상병리학적 검사결과의 변동

In order to know the kinds of liver function tests which are applicable to the hepatotoxicity experiment in Korean black goats, 0.3ml of carbon tetrachloride per kilogram body weight was injected intraruminally in 6 Korean black goats and 8 liver function tests were performed sequentially during the 14-day experimental course. Serum total bilirubin concentration, serum alkaline phosphatase activity and BUN concentrotion were suggested not to be applicable to the hepatotoxicity experiment in Korean black goats as they were not altered significantly during the 14-day experimental course. Indocyanine green T 1/2, Serum AST, SDH, gamma-GTP, and OCT activities were suggested to be applicable as sensitive indicators to the hepatotoxicity experiment in Korean black goats.