Synthesis and Antibacterial Activities of New $\beta$-Lactam Compounds

새로운 $\beta$-락탐계 물질의 합성 및 그 항균력

  • Published : 1986.12.01

Abstract

New antibiotics having moieties of penicillanic acid, cephalosporanic acid and ampicillin on both ends of the central polyalkylene were synthesized by reacting 6-aminopenicillanic acid (6-APAl), 7-amino cephalosporanic acid (7-ACA) and ampicillin with hexamethylene diisocyanate and sebacoyl chloride, respecetively. Antibiacterial activities of the compounds were also investigated.

Keywords

References

  1. Recent Advances in the Chemistry of β-Latam Antibiotics Elko,J.
  2. The Organic Chemistry of Drug Synthesis Lednicer,D.;Mitscher,L.A.
  3. Cephalosporins and Penicillins Flynn,E.H.
  4. Biochem, J. v.58 Newton,G.G.F.;Abraham,E.P.
  5. Topics in Antibiotics Chemistry v.4 Sammes,P.G.
  6. Beta-lactam Antibiotics Mitsuhashi,S.
  7. Peptide Synthesis Bodanszy,M.;Klausner,Y.S.;Ondetti,M.A.
  8. J. Antibiotics v.27 Ferres,H.;Basker,M.J.;O'Hanlon,P.J.
  9. British Patent 1,483,416
  10. Japan Patent 79-1411
  11. Clinical Microbiology and Micology Wolf, Lassel;Shimoda
  12. 대한약전(제3개정) 대한약사회(편)
  13. Antibiotics in Laboratory Medicine Lorian,V.
  14. Peptide Synthesis Bodanszy,M.;Klausner,Y.S.;Ondetti,M.A.
  15. Thin-layer chromatography Stahl,E.