YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Griseofulvin-Phenobarbital Interaction (I) -Pharmacokineties of Griseofulvin in Phenobarbital-pretreated Rats-

그리세오풀빈-페노바르비탈 상호작용 (I) -페노바르비탈 전처리 Rat에 있어서 그리세오풀빈의 생체내 동태-

  • Published : 1986.12.01
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Abstract

Effects of phenobarbital on the pharmacokinetics of griseofulvin were studied in rats. Phenobarbital was administered orally for five days at the dose of 75mg/kg/day. Absolute bioavailability of oral griseofulvin was significantly(p<0.005) reduced but total clearance(CL$_s$ was not changed by phenobarbital pretreatment. Absorption rate constant(K$_a$ and maximum plasma concentration(C$_{max}$) were significantly(p<0.05) reduced, and time to reach maximum plasma concentration(T$_{max}$) of griseofulvin was significantly(p<0.05) increased by phenobarbital pretreatment. Changed pharmacokinetics of griseofulvin seemed not to be due to induced enzyme activity by phenobarbital but to reduced GI absorption of griseofulvin.

Keywords

References

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