Antineoplastic Natural Products and the Analogues(X) -Antitumor Activity of Trichosanthes kirillowii on L1210 and S-180 Tumors-

항암성 천연물및 그 유사체(X) - L1210 및 S-180에 대한 하늘타리의 항암성

A strongly cytotoxic fraction (Fc-2, ED50=0.0003$\mu\textrm{g}$/ml) against L1210 cell was obtained from the root, seed and fruit of Trichosanthes kirilowii. Administration of Fc-2 prolonged the life span of the BDF1 mice bearing L1210 and the ICR mice bearing S-180 by 135%, and 130%, respectively. The Fc-2 affected L1210 cells were enlarged in their diameters two or three times in comparison with the untreated ones. When 20mg/kg of Fc-2 was administered, intraperitoneally, all the mice were killed.