Studies on the Efficacy of Combined Preparation of Crude Drugs(XXXII) -The Effect of Shihogesikungang-tang on the Central Nervous and Cardiovascular Systems-

생약(生藥) 복합제제(複合製劑)의 약효(藥效) 연구(硏究)(제32보)(第32報) -시호계지건강탕(柴胡桂枝乾薑湯)이 중추신경계(中樞神經系) 및 순환기계(循環器系)에 미치는 영향(影響)-

This study was conducted about the effect of Shihogesikungang-tang on the central nervous system and cardiovascular system for the investigation of its clinical effect based on the Oriental medicinal references. The results of this study were summerized as follows; Analgesic activity as evaluated by the writhing syndrome in mice was significantly noted. A decrease effect of the spontaneous movement as estimated by wheel cage method, muscle relaxant effect as evaluated by the rotor rod method and the prolonged effect of sleeping time induced by thiopental-Na were significantly shown in mice. A antipyretic activity in febrile rats induced by the endotoxin was recognized. Anti-inflammatory effect in carrageen-induced paw edema in rats was significantly noted. Negative inotropic action on the isolated heart of frogs was noted. A vasodilative action in rabbits peripheral blood vessels and hypotension in anesthetized rabbits were remarkably recognized.