Archives of Pharmacal Research

The Pharmaceutical Society of Korea (대한약학회)
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Studies on Triterpenoid Corticomimetics (VI) - Anti-inflammatory Activities of 11-Keto-derivatives of Pomolic Acid, $\beta$-Boswellic Acid and Presenegenin

  • Han, Byung-Hoon (Natural Products Research Institute, Seoul National University) ;
  • Han, Yong-Nam (Natural Products Research Institute, Seoul National University) ;
  • Park, Eun-Tae (College of Pharmacy, Sookmyung Womens University) ;
  • Kim, Kyung-Mi (College of Pharmacy, Sookmyung Womens University) ;
  • Kim, Tae-Hee (College of Pharmacy, Sookmyung Womens University)
  • Published : 1985.12.01
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Abstract

11-Keto-derivatives of pomolic acid, $\beta$-boswellic acid and presenegenin were compared with those of oleanolic acid, hederagenin and glycyrrhetinic acid in respects of inhibitions on corticoid-5.betha.-reductase and anti-inflammatory activities. Hyddrophilicity of ring A and hydrophobicity of rings C/D enhanced the inhibition on the enzyme. However, the former induced edema and the latter caused to exhibit anti-inflammatory activity.

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