• Archives of Pharmacal Research
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• v.8 no.4
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• pp.237-242
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• 1985

11-Keto-derivatives of pomolic acid, $\beta$-boswellic acid and presenegenin were compared with those of oleanolic acid, hederagenin and glycyrrhetinic acid in respects of inhibitions on corticoid-5.betha.-reductase and anti-inflammatory activities. Hyddrophilicity of ring A and hydrophobicity of rings C/D enhanced the inhibition on the enzyme. However, the former induced edema and the latter caused to exhibit anti-inflammatory activity.