Korean Journal of Pharmacognosy (생약학회지)
- Volume 16 Issue 1
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- Pages.1-6
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- 1985
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Effects of Patriniae Radix and Melandrii Herba on Enzyme Activities in Mice
-
Shin, Kuk-Hyun
(Natural Products Research Institute, Seoul National University)
;
- Woo, Won-Sick (Natural Products Research Institute, Seoul National University) ;
- Lee, Chung-Kyu (Department of Pharmacy, Busan Sanub University)
- Published : 1985.03.30
Abstract
Effect of various fractions from the roots of Patrinia scabiosaefolia (Valerianaceae) and whole plants of Melandryum firmum (Caryophyllaceae) on enzyme activities in mice was investigated. The butanol fractions from both plants caused a significant elevation of serum transaminase activities when administered intraperitoneally, but did not, orally. Prolonged exposure by oral administration of both plants elevated hepatic cytochrome p-450 content, indicating the induction of drug metabolizing enzymes in liver.
Keywords
- Patrinia scabiosaefolia;
- Valerianaceae;
- Melandryum firmum;
- Caryophyllaceae transaminase;
- alkaline phosphatase;
- cytochrome p-450