Studies on the Efficacy of Combined Preparation of Crude Drugs (XX) -Effects of Tongkyu-tang on Analgesic, Antipyretic, Sedative, Anti-inflammatory, Isolated Ileum and Antihistaminic Activities-

생약(生藥) 복합제제(複合製劑)의 약효(藥效) 연구(硏究)(제20보)(第20報) -통규탕(通竅湯)이 진통(鎭痛), 해열(解熱), 진정(鎭靜), 항부종(抗浮腫), 적출장관(摘出腸管) 및 항(抗)히스타민작용(作用)에 미치는 영향(影響)-

Experimental studies were conducted to investigate for the effect of Tongkyu-tang on analgesic, antipyretic, sedative, anti-inflammatory, isolated ileum and anti-histamine actions. Tongkyu-Tang was composed of sixteen crude drugs including Astragali Radix, which has been used for the treatment of common cold, headache, rhinitis, nasal obstruction, rhincospasm, etc. The following results have been obtained; analgesic and antipyretic actions were obtained. Prolonged action against the hypnotic duration of pentobarbital were significantly noted in mice. Anti-inflammatory effects in the paw edema induced by 1% carrageenin and 1% dextran were significantly shown in rats. Spontaneous motilities of isolated ileum of mice were strongly suppressed, and contractions of isolated ileum of mice and guinea-pigs induced by acetylcholine chloride, barium chloride and histamine were remarkably inhibited. Antihistamine actions were noted. Considering the above experimental results, it is suggested that effects of Tongkyu-tang based on the Oriental Medical References were similarly consistent with the actual experimental results.