생약복합제(生藥複合劑)의 약효연구(藥效硏究) 제5보(第5報) -황연해독탕(黃連解毒湯)이 부종(浮腫), 장관(腸管), 혈압(血壓), 혈당량(血糖量), 총(總)코레스테롤 함량(含量) 및 항균작용(抗菌作用)에 대(對)하여-

Studies on the Efficacy of Combined Preparation of Crude Drugs (V) -Effect of ‘Whangryonhaedok-Tang’ on the Anti-inflammatory, Ileum of Mice, Blood Pressure, Blood Glucose, Total Cholesterol and Antibacterial Activity-

In order to investigate the effect of 'Whangryonhaedok-Tang' on the anti-inflammatory, ileum of mice, blood pressure, blood glucose, total cholesterol and antibacterial activity, those pharmacological actions were conducted. The results of this studies were summarized as follows; Rat hind paw edema induced by acetic acid was inhibited. In mice, tone of intestinal smooth muscle was suppressed with the treatment of sample and intestinal contractions induced by $BaCl_2$ was inhibited. Hypertensive effect was not observed in rabbits but was observed by the water extract of 'Whangryonhaedok-Tang' excluded Phellodendri Cortex in rabbits. The increased blood glucose levels in alloxandiabetic rabbits were significantly decreased by the oral administration of the sample I after 6 days. The total cholesterol levels in alloxan-induced rabbits were significantly decreased by the oral administration of the sample I after 9 days. Antibacterial activity was observed. In addition, we thought the pharmacological actions were significantly noted by the sample III (Methanol soluble fraction) because of the purification of effective components.