The Korean Journal of Zoology (한국동물학회지)

The Korean Society for Integrative Biology (한국통합생물학회)
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Cytocidal Effect of Hyperthermia on Tumor Cells in vivo

In vivo 腫瘍細胞에 미치는 溫熱處理의 細胞致死效果

  • Kang, Man-Sik (Dept. of Zoology, Seoul National University) ;
  • Rhee, Jeong-Gile (Dept. of Therapeutic Radiology, University of Minnesota) ;
  • Seymour H. Levitt (Dept. of Therapeutic Radiology, University of Minnesota) ;
  • Chang W. Song (Dept. of Therapeutic Radiology, University of Minnesota)
  • Published : 1981.04.01
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Abstract

The cytocidal effect of hyperthermia on subcutaneous SCK tumor cells growing in vivo was significantly greater than that on the SCK tumor cells cultured in vitro. When the tumors were left in situ after heating, the cell survival progressively decreased, and the functional intratumor vascular volume also decreased. The radiation survival curves of tumor cells heated either 30 min before or after X-irradiation in vivo were steeper than the radiation survival curves of unheated control tumors. It is concluded that the cytocidal effect of hyperthermia on tumor cells in vivo is greater than that in vitro due possibly to the intratumor environment.

SCK 腫瘍細胞에 대한 溫熱處理의 細胞致死效果는 in vitro의 경우보다 in vivo의 경우에 顯著하게 컸다. In vivo에서 溫熱處理한 후, 腫瘍을 그대로 放置해두면 腫瘍細胞는 어느 期間동안 계속해서 죽게 되며 腫瘍의 機能的인 血管容積도 마찬가지로 減少한다. In vivo에서 X線을 照射하기 前과 後 30分에 溫熱處理한 腫瘍細胞의 放射線生殘曲線은 溫熱處理하지 않은 對照群의 그것에 比해 기울기가 컸다. 結論的으로 腫瘍細胞에 대한 溫熱處理의 細胞致死效果가 in vitro에 비해서 in vivo의 경우에 크게 되는 것은 腫瘍의 內部環境에 연유하는 것으로 생각된다.

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