The Korean Journal of Mycology (한국균학회지)

The Korean Society of Mycology (한국균학회)
권호 표지

Studies on Constituents and Culture of the Higher Fungi of Korea(XXV) -Stimulatory Effects of Coriolus versicolor Constituents on Immune Response-

한국산(韓國産) 고등(高等) 균류(菌類)의 성분(成分) 및 배양(培養)에 관한 연구(硏究)(XXV) -구름버섯 항암성분의 면역 촉진 효과-

  • Shim, Mi-Ja (Department of Microbial Chemistry, College of Pharmacy, Seoul Nationl University)
  • 심미자 (서울대학교 약학대학 미생물약품화학교실)
  • Published : 1980.09.30
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Abstract

To investigate mechanism of antineoplastic activities of the protein-polysaccharide fraction of Coriolus versicolor (Fr.) Quel., the mycelium of the fungus was grown in a liquid medium and was extracted with hot water. The extract was purified and used for examining its effects upon immune response in mice. The fraction was administered at a dose of 20mg/kg/day to ICR mice for five days. After ten days the mice were immunized by sheep red blood cells. The plaque-forming cells (PFC) in their spleen were increased in the treated mice. The number of PFC in case of the protein-removed polysaccharide was lower than that of the entire protein-­polysaccharide fraction of the fungus.

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