The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
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Plasma Renin Activity in Diabetes Mellitus

당뇨병(糖尿病)에서의 혈장(血漿) Renin 활성(活性)에 관(關)한 연구(硏究)

  • Pyo, Heui-Jung (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Part, Jung-Sik (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Kim, Sung-Kwon (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Choi, Kang-Won (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Lee, Jung-Sang (Department of Internal Medicine, College of Medicine, Seoul National University) ;
  • Lee, Mun-Ho (Department of Internal Medicine, College of Medicine, Seoul National University)
  • Published : 1979.11.20
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Abstract

To evaluate the renin-angiotensin-aldosterone system in diabetes mellitus, basal plasma renin activity (PRA) and its response to intravenous furosemide were determined in 40 diabetic subjects. The diabetics were divided into 4 groups according to the pressence of nephropathy and/or hypertension. Uncomplicated diabetics (Group I) were taken as control group and the results of the ether groups were compared to this group. In diabetics with nephropathy alone (Group II), and with nephropathy and hypertension (Group III), basal PRA values were $0.63{\pm}0.59ng/ml/hr.,\;and\;0.79{\pm}0.62ng/ml/hr.,$ respectively, both significantly lower than control group. ($1.53{\pm}1.09ng/ml/hr.$). (p<0.05) In both of the above groups, the responses to intravenous furosemide tended to be blunted. On the other hand, in diabetics with hypertension only (Group IV), the basal and stimulated PRA were not significantly different from control. Above results suggests that nephropathy may be one of the factors which suppress renin activity in diabetes mellitus.

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