The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

The Distribution of Estrogen Receptor in Various Organs of Rabbit

토끼 각장기의 Estrogen 수용체의 분포

  • Son, Ho-Young (Department of Internal Medicine, Catholic Medical College) ;
  • In, Jae-Whan (Department of Internal Medicine, Catholic Medical College) ;
  • Min, Byong-Sok (Department of Internal Medicine, Catholic Medical College)
  • 손호영 (가톨릭대학 의학부 내과학교실) ;
  • 인재환 (가톨릭대학 의학부 내과학교실) ;
  • 민병석 (가톨릭대학 의학부 내과학교실)
  • Published : 1978.12.30
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Abstract

For clinical application of radioreceptor assay, we studied preliminarily the distribution of estrogen receptor in various organs of rabbit by a dextran-charcoal method using $6,7-^3H-estradiol$. The results were expressed as binding index, which is the ratio of specific estradiol receptor binding radioactivity to total radioactivity. The materials consist of 5 female rabbits and 3 male rabbits. The results were as follows: 1) Female rabbits The binding index was highest in the uterine tissue. This binding index of the uterine tissue was 9.4 times that of the liver, 21.9 times that of the kidney, 24.6 times that of the brain, 28.1 times that of the lung and 65.7 times that of the muscle. 2) Male rabbits The binding index was highest in the liver and decreased in the order of the kidney, the testis, the lung, the brain and the muscle. It is suggested that the estrogen receptor is not confined to any specific target organ but is widely distributed in the various organs, to a different degree.

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