Journal of Microbiology and Biotechnology
- Volume 5 Issue 1
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- Pages.36-40
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- 1995
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- 1017-7825(pISSN)
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- 1738-8872(eISSN)
Valistatin (3-Amino-2-Hydroxy-4-Phenylbutanoyl-Valyl-Valine), a New Aminopeptidase M Inhibitor, Produced by Streptomyces sp. SL20209
- Kho, Ying-Hee (Microbial Chemistry R.G., Genetic Engineering Research Institute, KIST) ;
- Ko, Hack-Ryong (Microbial Chemistry R.G., Genetic Engineering Research Institute, KIST) ;
- Chun, Hyo-Kon (Microbial Chemistry R.G., Genetic Engineering Research Institute, KIST) ;
- Jung, Myung-Chul (Microbial Chemistry R.G., Genetic Engineering Research Institute, KIST)
- Published : 1995.03.01
Abstract
Valistatin, a new inhibitor of aminopeptidase M(AP-M) was discovered in the culture broth of Streptomyces sp. SL20209 isolated from a soil sample. The inhibitor was purified by extraction with n-butanol and the various column chromatographies, and then isolated as whitish powder. The