약학회지 (YAKHAK HOEJI)
- 제20권3호
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- Pages.130-137
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- 1976
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
A Spectroscopic Study of Hydrogen Bonding between Riboflavin and Salicylic Acid Derivatives
- Huh, Jae-Wook (College of Pharmacy, Seoul National University) ;
- Yu, Byung-Sul (College of Pharmacy, Seoul National University)
- 발행 : 1976.09.01
초록
Specific association phenomena of riboflayin-2',3',4',5',- tetraacetate and salicylic acid derivatives, such as salicylic acid, aspirin and salicylamide have been measured by infrared and fluorescence spectroscopy. Salicylic acid and riboflavin tetraacetate oxyl group of the former. Asprin and riboflavin tetraacetate form the 1:1 cyclic hydrogen bonded dimer by the same mode. Salicylamide froms the 1:1 cyclic hydrogen bonded dimer with riboflavin tetraacetate by using its amide group and carbonyl group. Salicylic acid derivatives are effective quenchers of the fluorescence of riboflavin tetraacetate. It is appeared that salifylamide is the strongest quencher among them. The quenching effect is attributed to the formation of association dimer.
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