약학회지 (YAKHAK HOEJI)
- 제20권3호
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- Pages.125-129
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- 1976
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
Gas-liquid Chromatographic Analysis of Some Tropane Alkaloids
- Paik, Nam-Ho (College of Pharmacy, Seoul National University) ;
- Im, Yong-Bin (College of Pharmacy, Seoul National University) ;
- Park, Man-Ki (College of Pharmacy, Seoul National University)
- 발행 : 1976.09.01
초록
The aim of this investigation was to develop a quantitative gas-liquid chromatographic method of analysis forhyosyamine and scopolamine, and to apply this method to the analysis of preparations. The trimethylsily(TMS) derivatives of the alkaloids were found to be far superior to the nonsilylating compounds in charomatagrams. Bis(trimethylsilyl) acetamide(BSA) was evaluated and found to be a good reagent for silyation of the alkaloids. The optimum derivatization conditions were heating the alkaloids in a closed tube at
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