A Biopharmaceutical Study on the Absorptive Effect of Some Compounding Drugs(IV) -Effect on the Writhing Syndrome of Salicylamide Combined with Chlorpheniramine Maleate-

배합약물(配合藥物)의 흡수효과에 관(關)한 생물약제학적(生物藥劑學的) 연구(硏究)(IV) -Salicylamide에 Chlorpheniramine Maleate를 배합투여(配合投與)하였을 경우의 Writhing Syndrome에 미치는 영향(影響)에 관(關)하여-

The intentional test of the clinical test on the mouse, which are orally administered salicylamide combined with chlorpheniramine maleate were made by writhing syndrome method of 0.7% acetic acid-saline solution and following effects were found. 1) The cross-over test of writhing syndrome method have intention in case of three days rest after the first examination. 2) The most active rate of salicylamide by administration combined with chlorpheniramine maleate is salicylamide 20mg/kg: chlorpheniramine maleate 20mg/kg (1:1) 3) The most active range of chlorpheniramine maleate used for assistant action of salicylamide is $15mg/kg{\sim}20mg/kg$