분말성제제(粉末性製劑)의 안정성(安定性)에 관(關)한 연구(硏究) -제제중(製劑中)의 Ascorbic Acid의 분해(分解)에 미치는 Talc의 영향(影響)-

Study on the Effect of Talc on the Degredation of Ascorbic Acid in its Diluted Preparation

There are many reports on the stability of drugs in powders and various dosage forms. The author studied on the stability of ascorbic acid mixed with talcs. From the result of this experiment, it was considered that talcs markedly accelerated oxidative degredation of ascorbic acid in powders and the acceleration rate depends on the varieties of crude talcs. Iron salts seem to be the principal factor influencing the degradation of ascorbic acid Degradation rate of ascorbic acid mixed with purified talc is significantly slower than that with the crnde talcs. The more the concetration of ascorbic acid is diluted, the faster the degradation rate and degredation rate of Ascorbic acid is the function of tme.