제제(製劑)의 효율에 관(關)한 연구(硏究) 1. Computer를 이용(利用)한 일차(一次) 흡수소실(吸收消失) model에서의 효율 및 흡수속도계산(吸收速度計算)

Studies on the Drug Availability of Dosage Forms I. Computer Calculation for the Rats of Absorption and Availability in a Pharmacokinetic Model

The method of assessing drug availability has been the subject of much concern and the equation is presented to estimate the drug availability of dosage forms and to calculate the desirable rates of drug absorption in a model. $Xmax/X_0=(k_1/k_2)^{{\frac{1}{1-^-k_1/k_2}}}$ To facilitate the calculations involved in the equation, a program in Fortran with Format was used in the IBM 1130 digital computer system. Using availability, $Xmax/X_0$, and the given rates of elimination from the blood, the desirable rates of drug absorption in the model were calculated and shown in detail. Applicabiliy of the equation to estimate the drug availability of dosage forms in the model was demonstrated with different sets of data from the literatures.