한국자원식물학회:학술대회논문집 (Proceedings of the Plant Resources Society of Korea Conference)
- 한국자원식물학회 2019년도 추계학술대회
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- Pages.66-66
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- 2019
Anti-inflammatory Effect of Heracleum moellendorffii Roots through the Inhibition of NF-κB and MAPK Signaling, and Activation of ROS/Nrf2/HO-1 Signaling in LPS-stimulated RAW264.7 Cells
- Park, Su Bin (Department of Medicinal Plant Resources, Andong National University) ;
- Kim, Ha Na (Department of Medicinal Plant Resources, Andong National University) ;
- Kim, Jeong Dong (Department of Medicinal Plant Resources, Andong National University) ;
- Jeong, Jin Boo (Department of Medicinal Plant Resources, Andong National University)
- 발행 : 2019.10.18
초록
Heracleum moellendorffii roots (HM-R) have been long treated for inflammatory diseases such as arthritis, backache and fever. However, an anti-inflammatory effect and the specific mechanism of HM-R were not yet clear. In this study, we for the first time explored the anti-inflammatory of HM-R. Results: HM-R dose-dependently blocked LPS-induced NO and PGE2 production. In addition, HM-R inhibited LPS-induced overexpression of iNOS, COX-2,