Interdigitated Microelectrode Lab-on-a-chip sensing system for Biomoelcule Detection

마이크로패턴된 전극을 이용한 실시간 생체물질 감지 랩칩 시스템

Recently, Alzheimer's Disease (AD) is one of the biggest threats to healthy society. Current medical AD diagnosis depends on interviews and the molecular neuroimaging. There is no cure for the disease, which worsens as it progresses, and eventually leads to death. Amyloid ${\beta}$ and Tau-meditated neuronal injury and dysfunction are candidates of biomarker for AD diagnosis using blood. For highly sensitive and selective biosensor platform, interdigitated microelectrodes (IMEs) sensor was prepared with micro fabrication process and Amyloid ${\beta}$ antibody. Amyloid ${\beta}$ concentration of 1, 10, 100, and 1000 pg/mL was injected in reaction chamber with IME sensors, impedance and conductance of IMEs changed respectively. These results show our newly proposed IMEs sensor can be usefully utilized for AD early diagnosis.