Proceedings of the Materials Research Society of Korea Conference (한국재료학회:학술대회논문집)

Materials Research Society of Korea (한국재료학회)
권호 표지

Fabrication and Characterization of Electrospun PLGA/Gelatin Nanofiber Tube for Potential Intestinal Stent Application

  • Son, So-Ra (Department of Biomedical Engineering and Materials, Soonchunhyang University) ;
  • Franco, Rose-Ann (Department of Biomedical Engineering and Materials, Soonchunhyang University) ;
  • Bao, Trinh-Quang (Department of Biomedical Engineering and Materials, Soonchunhyang University) ;
  • Bae, Sang-Ho (Department of Surgery, Soonchunhyang university hospital) ;
  • Min, Young-Ki (Department of physiology, Soonchunhyang University) ;
  • Lee, Byong-Taek (Department of Biomedical Engineering and Materials, Soonchunhyang University)
  • Published : 2011.05.27
Download PDF
⟨ Previous Next ⟩

Abstract

An electrospun Poly (lactice-co-glycolide acid) (PLGA) and Gelatin nanofiber tube was fabricated for potential intestinal stent application. Mechanical properties of tube were evaluated by tensile strength and burst strength tests. Physical and chemical properties were evaluated by contact angle measurement, swelling rates and porosity measurements. Biodegradability was investigated by immersion in simulated body fluid (SBF). Biocompatibility was investigated in vitro by cytotoxicity and proliferation studies by MTT assay, confocal microscopy and western blot using IEC-18 (Rat intestinal epithelial cell). After intestinal stent was implanted into rat bowel for periods from 7 to 10days, it was then analyzed using micro-computed tomography (Micro CT) and X-ray techniques. Futhermore, histological analysis was performed by hematoxylin-eosin (H&E) stain.

Keywords