Proceedings of the Materials Research Society of Korea Conference (한국재료학회:학술대회논문집)

Materials Research Society of Korea (한국재료학회)
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Implantation of Small Artery Vessel from Blends PCL/PU with and without Anti-thrombus

  • Hiep, Nguyen Thi (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University) ;
  • Lee, Seong-Jin (Department of Thoracic and Cardiovascular Surgery, Chunan Hospital, Soonchunhyang University) ;
  • Min, Young-Ki (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University) ;
  • Yang, Hun-Mo (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University) ;
  • Song, Ho-Yeon (Department of Immunology, College of Medicine, Soonchunhyang University) ;
  • Lee, Byong-Taek (Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University)
  • Published : 2010.05.13
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Abstract

In this experiment, artificial blood vessel was fabricated from electro-spun PU/PCL. To assist with endothelial growth, PU/PCL surface was coated with the RGD peptide. To prevent a clot of blood, anti-thrombus agent was loaded to the fibrous mat and values were reflected through FT-IR data. In vitro study, SEM and MTT data showed that the component was of excellent biocompatibility and cell proliferation. In in vivo study, the artificial blood vessel was implanted in a dog's artery. The results of the CT scan, ultrasound and H&E staining showed that artificial blood vessel was excellent for artery replacement applications.

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