Proceedings of the IEEK Conference (대한전자공학회:학술대회논문집)
- 2009.05a
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- Pages.135-137
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- 2009
An HIV model with CTL and drug-resistant mutants, and optimal drug scheduling
CTL과 바이러스 변이를 고려한 HIV 모형과 최적 제어를 이용한 약물 투여 전략
Abstract
Mathematical models for describing the Human Immunodeficiency Virus(HIV) infection can be devised to better understand how the HIV causes Acquired Immune Deficiency Syndrome(AIDS). The HIV models can then be used to find clues to curing AIDS from a control theoretical point of view. Some models take Cytotoxic T Lymphocytes(CTL) response to HIV infection into account, and others consider mutants against the drugs. However, to the best of our knowledge, there has been no model developed, which describes CTL response and mutant HIV together. Hence we propose a unified model to consider both of these. On the basis of the resulting model, we also present a Model Predictive Control(MPC) scheme to find an optimal treatment strategy. The optimization is performed under the assumption that the Structured Treatment Interruption(STI) policy is employed.