Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)
- 2004.06a
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- Pages.226-226
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- 2004
A 40 Kb Genomic Deletion Including tmie (Transmembrane Inner Ear Protein) Gene Causes Deafness, Circling and Head Tossing in Circling Mice
- Kyoung In Cho (Catholic Research Institutes of Medical Science, Catholic Medical College, Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University) ;
- Jeong Woong Lee (Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
- Eun Ju Lee (Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
- Sol Ha Hwang (Catholic Research Institutes of Medical Science, Catholic Medical College, Department of Medical Genetics and Experimental Animal Center, College of Medicine, Hallym University) ;
- Myoung Ok Kim (Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
- Sung Hyun Kim (Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
- Jun Hong Park (Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
- Boo Kyoung Jung (Catholic Research Institutes of Medical Science, Catholic Medical Colleg) ;
- Hee Chul Kim (Catholic Research Institutes of Medical Science, Catholic Medical College)
- Published : 2004.06.01
Abstract
Circling (cir) mouse is a spontaneous mutant in the inner ear that was first reported in Korea. The mutation is transmitted by an autosomal recessive gene with 100 %- penetrance.. Homozygous mice are characterized by head-tossing, bi-directional circling behavior and deafness. Histologicalexamination of the inner ear reveals abnormalities of the region around the organ of Corti, spiral ganglion neurons, and outer hair cells. (omitted)