Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)

The Korean Society of Animal Reproduction (한국동물번식학회)
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Gene Targeting in Mouse Embryos Mediated by recA and Modified Single-Stranded Oligonucleotides

  • Kang, Jee-Hyun (Department of Physiology, Dankook University School of Medicine) ;
  • Won, Ji-Young (Department of Physiology, Dankook University School of Medicin) ;
  • Heo, Soon-Young (Department of Physiology, Dankook University School of Medicin) ;
  • Hosup Shim (Department of Physiology, Dankook University School of Medicine)
  • Published : 2004.06.01
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Abstract

Gene targeting is an in situ manipulation of endogenous gene with precise manner by the introduction of exogenous DNA. The process of gene targeting involves a homologous recombination reaction between the targeted genomic sequence and an exogenous targeting vector. In elucidating the function of many genes, gene targeting has become the most important method of choice. (omitted)

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