Proceedings of the KSAR Conference (한국동물번식학회:학술대회논문집)

The Korean Society of Animal Reproduction (한국동물번식학회)
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Regulation of Histone Acetylation during First Mitosis in Bovine Clone Embryos

  • Gabbine Wee (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology) ;
  • Koo, Deog-Bon (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Kang, Man-Jong (Department of Animal Science, Chonnam National University) ;
  • Moon, Seung-Ju (Department of Animal Science, Chonnam National University) ;
  • Lee, Kyung-Kwang (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnolog) ;
  • Han, Yong-Mahn (Laboratory of Development and Differentiation, Korea Research Institute of Bioscience and Biotechnology)
  • Published : 2004.06.01
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Abstract

Histone acetylation as epigenetic marker plays a critical role in gene expression through the interaction of nucleosomes with DNA, modulating the efficiency which RNA-polymerase can interact with promotors to initiate transcription. After fertilization, highly acetylated chromatin takes place and maintain during 1cell stages. The hyperacetylation may lead minor genome activation for survival and cleavage, and then may affect embryonic genome activation and development to balstocyst. (omitted)

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