Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.235.2-235
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- 2003
Buccal Mucosal Ulcer Healing Effect of rhEGF by Using Mucoadhesive Formulations
- Park, Jeong-Sook (College of Pharmacy, Chungbuk National University) ;
- Kang, Soo-Hyun (College of Pharmacy, Chungbuk National University) ;
- Li, Hong (College of Pharmacy, Chungbuk National University) ;
- Han, Kun (College of Pharmacy, Chungbuk National University)
- Published : 2003.10.01
Abstract
To develop the buccal delivery system of rhEGF for the treatment of buccal mucosal ulcer, polymer films and hydrogels were investigated. Methods: Hydrogels for thermosenstive sol/gel systems were prepared by the cold method (Schmolka, 1972). And mucoadhesive films were prepared by mixing sod. alginate/polycarbophil 974p. To find an optimum buccal mucosal adhesive gel or film, the gel strength of the poloxamer and sod. alginate/polycarbophil 974p hydrogels were determined by the Simple Rheology Method and their mucoadhesiveness were measured by the Instron (M 4400, Instron Co., U.S.A.) method. (omitted)
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