Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.235.1-235.1
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- 2003
Biocompatible polymeric rods as implants for enhanced cartilage regeneration
- Yook , Yeo-Joo (College of Pharmacy, Ewha Womans University) ;
- Hwang, Jeong-Hyo (Seoul National University Hospita) ;
- Shim, In-Kyung (Seoul National University Hospita) ;
- Lee, Jue-Yeon (Seoul National University Hospita) ;
- Lee, Sang-Young (Seoul National University Hospita) ;
- Ahn, Hyun-Jeong (Seoul National University Hospita) ;
- Lee, Sang-Hoon (Seoul National University Hospita) ;
- Lee, Myung-Chul (Seoul National University Hospita) ;
- Lee, Seung-Jin (Seoul National University Hospital)
- Published : 2003.10.01
Abstract
With an aim of obtaining high efficacy in cartilage regeneration, implantable polymeric rods were fabricated. These rod-type matrices were anticipated to perform structural tissue supporting activity and enhance extracellular matrix (ECM) formation by releasing specific agent, DHEA-S, in controlled manner. It is expected that application for the drilling operation on the articular cartilage of OA patients as the implants may promote regeneration of their cartilage. Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage, subchondral bone remodeling, spur formation, and synovial inflammation. (omitted)
Keywords