힘반향 기반의 바이오매니퓰레이션을 위한 세포 조작력 측정

Cellular Force Measurement for Force Feedback-Based Biomanipulation

  • 김덕호 (한국과학기술연구원 마이크로시스템연구센터) ;
  • 김병규 (한국과학기술연구원 마이크로시스템연구센터) ;
  • 윤석 (한국과학기술연구원 마이크로시스템연구센터) ;
  • 강현재 (한국과학기술연구원 마이크로시스템연구센터)
  • 발행 : 2003.06.01

초록

In biological cell manipulation, manual thrust or penetration of an injection pipette into an embryo cell is currently performed by a skilled operator, relying on visual feedback information only. Accurately measuring cellular forces is a requirement for minimally invasive cell injections. Moreover, the cellular farce sensing is essential in investigating the biophysical properties for cell injury and membrane modeling studies. This paper presents cellular force measurements for the force feedback-based biomanipulation. Cellular force measurement system using piezoelectric polymer sensor is implemented to measure the penetration force of a zebrafish egg cell. First, measurement system setup and calibration are described. Second, the force feedback-based biomanipulation is experimentally carried out. Experimental results show that it successfully supplies real-time cellular force feedback to the operator at several tens of uN and thus plays a main role in improving the reliability of biological cell injection tasks.

키워드