Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.245.2-245.2
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- 2003
Determination of Prazosin in Human Plasma Using a Validated HPLC Method and Bioavaliability of a Tablet Formulation
- Oh, Jung-Hyun (Chosun University, College of Pharmacy) ;
- Cho, Young-Ah (Dongduk Women's University, College of Pharmac) ;
- Gwak, Hye-Sun (Dongduk Women's University, College of Pharmac) ;
- Noh, Eun-Sun (Dongduk Women's University, College of Pharmac) ;
- Lee, Na-Young (Dongduk Women's University, College of Pharmac) ;
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Chun, In-Koo
(Dongduk Women's University, College of Pharmacy)
- Published : 2003.10.01
Abstract
A rapid and reproducible high performance liquid chromatographic assay of prazosin in human plasma was developed. After addition of internal standard (IS, terazosin hydrochloride) and alkalization of the plasma, the drug and IS were extracted into t-butylmethylether. The organic phase was back-extracted with 0.05% phosphoric acid and 50
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