Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
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- Pages.243.1-243.1
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- 2003
Pharmacokinetics of eupatilin, an active componets of Stillen\ulcorner, a new antigastritic agent,in rats
- Jang, Ji-Myun (Dong-A Pharmaceutical Co. LTD., 47-5, Sanggal-ri, Kitrung-up, Yongin-si, Kyunggo-do, 449-905) ;
- Park, Kyung-Jin (Dong-A Pharmaceutical Co. LTD., 47-5, Sanggal-ri, Kitrung-up, Yongin-si, Kyunggo-do, 449-905) ;
- Kim, Dong-Goo (Dong-A Pharmaceutical Co. LTD., 47-5, Sanggal-ri, Kitrung-up, Yongin-si, Kyunggo-do, 449-905) ;
- Shim, Hyun-Joo (Dong-A Pharmaceutical Co. LTD., 47-5, Sanggal-ri, Kitrung-up, Yongin-si, Kyunggo-do, 449-905) ;
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Ahn, Byung-Ok
(Dong-A Pharmaceutical Co. LTD., 47-5, Sanggal-ri, Kitrung-up, Yongin-si, Kyunggo-do, 449-905)
;
- Kim, Soon-Hoe (Dong-A Pharmaceutical Co. LTD., 47-5, Sanggal-ri, Kitrung-up, Yongin-si, Kyunggo-do, 449-905) ;
- Kim, Won-Bae (Dong-A Pharmaceutical Co. LTD., 47-5, Sanggal-ri, Kitrung-up, Yongin-si, Kyunggo-do, 449-905)
- Published : 2003.10.01
Abstract
The pharmacokinetics of eupatilin (an active components of Stillen, a new antigastritic agent) were investigated using UV-HPLC method. The quantitation limit of eupatilin was 10 ng/ml in plasma. After intravenous administration of eupatiln, 30 mg/kg to rats, the plasma concentrations of unchanged eupatilin declined rapidly with the mean terminal half-life of 0.101 hr. Total body clearance was 121 ml/min/kg, and fractions of dose excreted in urine and feces for 24 hr were only 2.5% and 0.919%, respectively. (omitted)
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