Proceedings of the PSK Conference (대한약학회:학술대회논문집)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Intravenous and Intra-arterial Delivery of Plasmid DNA/Cationic Lipiodol Emulsion Complexes

  • Chae, Min-Jung (Biomedical Research Center, Korea Institute of Science and Technology) ;
  • Chung , Hes-Son (Dept. of Pharmacy, Duksung Women's University) ;
  • Kwon, Ick-Chan (Biomedical Research Center, Korea Institute of Science and Technolog) ;
  • Chung, Jin-Wook (Dept. of Radiology, College of Medicine, Seoul National University) ;
  • Park, Jae-Hyung (Dept. of Pharmacy, Duksung Wome's University) ;
  • Sohn, Young-Taek (Dept. of Pharmacy, Duksung Wome's University) ;
  • Jeong, Seo-Young (Dept. of Pharmacy, Duksung Wome's University)
  • Published : 2003.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

A cationic lipid emulsion (o/w) containing lipiodol and 1, 2-dioleoyl-sn- glycero-3-trimethylammonium-propane (DOTAP) has been prepared as a gene delivery system. In order to increase the transfection efficiency of the lipiodol emulsion, 1 2-dioleoyl-sn-glycero-3-phospho-ethanolamine (DOPE) and polyoxyethylene sorbitan monooleate (Tween 80) were incorporated as additional lipids. By including DOPE and Tween 80, the cationic emulsion became a more potent gene carrier under in vitro condition in the presence of serum, and under in vivo condition. (omitted)

Keywords