Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2003.10b
- /
- Pages.220.3-220.3
- /
- 2003
Preparative Resolution of the Pindolol Enantiomers
- Shibru, Asegahegn-Workaferhaw (College of Pharmacy, Kangwon National University) ;
- Tran, Quoc-Trung (College of Pharmacy, Kangwon National University) ;
-
Kim, Kyeong-Ho
(College of Pharmacy, Kangwon National University)
- Published : 2003.10.01
Abstract
Enantiomers of pindolol were prepared by chromatographic method. Racemic pindolol was derivatized with S-(-)-menthyl chloroformate((-)-MCF) forming its diastereomer, R-(+)-pindolol-(-)-MCF and S-(-)-pindolol-(-)-MCF. The diastereomer mixture was then chromatographically resolved to each diastereomer. Each diastereomer was further hydrolyzed with alkali to each enantiomer quantitatively. Racemization was not occurred in this process. Pindolol enantiomers were recovered producing good yield over 30% over all process.
Keywords